Toxic metabolites also affect the autonomic nervous system regulating gastrointestinal motility, and this can causes abdominal pain, constipation, and vomiting.
The sympathetic nervous system is part of the autonomic nervous system and it helps mediate your automatic functions like breathing, heart rate, sweating, and digestion.
Plaques can also involve the autonomic nervous system which can lead to bowel and bladder symptoms like constipation and urinary incontinence, as well as sexual symptoms like sexual dysfunction.